Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection.
Identifieur interne : 001633 ( Main/Exploration ); précédent : 001632; suivant : 001634Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection.
Auteurs : Jincun Zhao [République populaire de Chine] ; Ranawaka A P M. Perera [République populaire de Chine] ; Ghazi Kayali [États-Unis] ; David Meyerholz [États-Unis] ; Stanley Perlman [États-Unis] ; Malik Peiris [États-Unis]Source :
- Journal of virology [ 1098-5514 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Chameaux, Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Femelle, Immunisation passive (), Infections à coronavirus (anatomopathologie), Infections à coronavirus (traitement médicamenteux), Modèles animaux de maladie humaine, Poumon (anatomopathologie), Résultat thérapeutique, Souris de lignée BALB C, Sérums immuns (administration et posologie).
- MESH :
- administration et posologie : Sérums immuns.
- anatomopathologie : Infections à coronavirus, Poumon.
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections à coronavirus.
- Animaux, Chameaux, Femelle, Immunisation passive, Modèles animaux de maladie humaine, Résultat thérapeutique, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Animals, Camelus, Coronavirus Infections (drug therapy), Coronavirus Infections (pathology), Disease Models, Animal, Female, Immune Sera (administration & dosage), Immunization, Passive (methods), Lung (pathology), Mice, Inbred BALB C, Middle East Respiratory Syndrome Coronavirus (immunology), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Immune Sera.
- drug therapy : Coronavirus Infections.
- immunology : Middle East Respiratory Syndrome Coronavirus.
- methods : Immunization, Passive.
- pathology : Coronavirus Infections, Lung.
- Animals, Camelus, Disease Models, Animal, Female, Mice, Inbred BALB C, Treatment Outcome.
Abstract
Middle East respiratory syndrome (MERS) is a highly lethal pulmonary infection. Serum from convalescent MERS patients may provide some benefit but is not readily available. In contrast, nearly all camels in the Middle East have been infected with MERS-CoV. Here, we show that sera obtained from MERS-immune camels augment the kinetics of MERS-CoV clearance and reduce the severity of pathological changes in infected lungs, with efficacy proportional to the titer of MERS-CoV-neutralizing serum antibody.
DOI: 10.1128/JVI.00446-15
PubMed: 25787284
Affiliations:
- République populaire de Chine, États-Unis
- Guangdong, Iowa, Tennessee
- Iowa City, Jiangmen
- Université de l'Iowa
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001673
- to stream PubMed, to step Curation: 001673
- to stream PubMed, to step Checkpoint: 001405
- to stream Ncbi, to step Merge: 001068
- to stream Ncbi, to step Curation: 001068
- to stream Ncbi, to step Checkpoint: 001068
- to stream Main, to step Merge: 001638
- to stream Main, to step Curation: 001633
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection.</title><author><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology, University of Iowa, Iowa City, Iowa, USA State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City, Iowa, USA State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Perera, Ranawaka A P M" sort="Perera, Ranawaka A P M" uniqKey="Perera R" first="Ranawaka A P M" last="Perera">Ranawaka A P M. Perera</name><affiliation wicri:level="1"><nlm:affiliation>The School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Kayali, Ghazi" sort="Kayali, Ghazi" uniqKey="Kayali G" first="Ghazi" last="Kayali">Ghazi Kayali</name><affiliation wicri:level="2"><nlm:affiliation>Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Meyerholz, David" sort="Meyerholz, David" uniqKey="Meyerholz D" first="David" last="Meyerholz">David Meyerholz</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Iowa, Iowa City, Iowa, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Iowa, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology, University of Iowa, Iowa City, Iowa, USA stanley-perlman@uiowa.edu malik@hku.hk.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name><affiliation wicri:level="1"><nlm:affiliation>The School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China stanley-perlman@uiowa.edu malik@hku.hk.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>The School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25787284</idno><idno type="pmid">25787284</idno><idno type="doi">10.1128/JVI.00446-15</idno><idno type="wicri:Area/PubMed/Corpus">001673</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001673</idno><idno type="wicri:Area/PubMed/Curation">001673</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001673</idno><idno type="wicri:Area/PubMed/Checkpoint">001405</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001405</idno><idno type="wicri:Area/Ncbi/Merge">001068</idno><idno type="wicri:Area/Ncbi/Curation">001068</idno><idno type="wicri:Area/Ncbi/Checkpoint">001068</idno><idno type="wicri:Area/Main/Merge">001638</idno><idno type="wicri:Area/Main/Curation">001633</idno><idno type="wicri:Area/Main/Exploration">001633</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection.</title><author><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology, University of Iowa, Iowa City, Iowa, USA State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City, Iowa, USA State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Perera, Ranawaka A P M" sort="Perera, Ranawaka A P M" uniqKey="Perera R" first="Ranawaka A P M" last="Perera">Ranawaka A P M. Perera</name><affiliation wicri:level="1"><nlm:affiliation>The School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author><author><name sortKey="Kayali, Ghazi" sort="Kayali, Ghazi" uniqKey="Kayali G" first="Ghazi" last="Kayali">Ghazi Kayali</name><affiliation wicri:level="2"><nlm:affiliation>Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee</wicri:regionArea><placeName><region type="state">Tennessee</region></placeName></affiliation></author><author><name sortKey="Meyerholz, David" sort="Meyerholz, David" uniqKey="Meyerholz D" first="David" last="Meyerholz">David Meyerholz</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Iowa, Iowa City, Iowa, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Iowa, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology, University of Iowa, Iowa City, Iowa, USA stanley-perlman@uiowa.edu malik@hku.hk.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name><affiliation wicri:level="1"><nlm:affiliation>The School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region, China stanley-perlman@uiowa.edu malik@hku.hk.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>The School of Public Health, The University of Hong Kong, Hong Kong Special Administrative Region</wicri:regionArea><wicri:noRegion>Hong Kong Special Administrative Region</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of virology</title><idno type="eISSN">1098-5514</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Camelus</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (pathology)</term><term>Disease Models, Animal</term><term>Female</term><term>Immune Sera (administration & dosage)</term><term>Immunization, Passive (methods)</term><term>Lung (pathology)</term><term>Mice, Inbred BALB C</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chameaux</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term><term>Femelle</term><term>Immunisation passive ()</term><term>Infections à coronavirus (anatomopathologie)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Modèles animaux de maladie humaine</term><term>Poumon (anatomopathologie)</term><term>Résultat thérapeutique</term><term>Souris de lignée BALB C</term><term>Sérums immuns (administration et posologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Immune Sera</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Sérums immuns</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Immunization, Passive</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Camelus</term><term>Disease Models, Animal</term><term>Female</term><term>Mice, Inbred BALB C</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Chameaux</term><term>Femelle</term><term>Immunisation passive</term><term>Modèles animaux de maladie humaine</term><term>Résultat thérapeutique</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome (MERS) is a highly lethal pulmonary infection. Serum from convalescent MERS patients may provide some benefit but is not readily available. In contrast, nearly all camels in the Middle East have been infected with MERS-CoV. Here, we show that sera obtained from MERS-immune camels augment the kinetics of MERS-CoV clearance and reduce the severity of pathological changes in infected lungs, with efficacy proportional to the titer of MERS-CoV-neutralizing serum antibody.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Guangdong</li><li>Iowa</li><li>Tennessee</li></region><settlement><li>Iowa City</li><li>Jiangmen</li></settlement><orgName><li>Université de l'Iowa</li></orgName></list><tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name></region><name sortKey="Perera, Ranawaka A P M" sort="Perera, Ranawaka A P M" uniqKey="Perera R" first="Ranawaka A P M" last="Perera">Ranawaka A P M. Perera</name></country><country name="États-Unis"><region name="Tennessee"><name sortKey="Kayali, Ghazi" sort="Kayali, Ghazi" uniqKey="Kayali G" first="Ghazi" last="Kayali">Ghazi Kayali</name></region><name sortKey="Meyerholz, David" sort="Meyerholz, David" uniqKey="Meyerholz D" first="David" last="Meyerholz">David Meyerholz</name><name sortKey="Peiris, Malik" sort="Peiris, Malik" uniqKey="Peiris M" first="Malik" last="Peiris">Malik Peiris</name><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001633 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001633 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:25787284
|texte= Passive immunotherapy with dromedary immune serum in an experimental animal model for Middle East respiratory syndrome coronavirus infection.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25787284" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |